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ARA-290 10MG
$90.00
This research-only product is supplied in a 3ml vial containing 10mg of ARA-290 (cibinetide) as a lyophilized powder. Every compound undergoes stringent independent 3rd-party testing in a US laboratory with verified 99%+ purity and a QR-linked COA stamped on the vial.
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For Research Purposes Only. This product is not intended for human consumption. By purchasing, you confirm that you are a qualified researcher and will use this product in compliance with all applicable laws and regulations.
Description
ARA-290, also known as cibinetide, is a defined synthetic 11-amino-acid peptide (undecapeptide) supplied as a sequence-verified reference compound for laboratory research. Its sequence corresponds to the helix-B surface region of erythropoietin (EPO), and it is engineered as a non-erythropoietic derivative — retaining tissue-protective signaling while lacking EPO’s red-blood-cell-stimulating activity.
Additional Information
ARA-290 was developed by Araim Pharmaceuticals as a selective agonist of the innate repair receptor (IRR), described as a heteromer of the EPO receptor (EPOR) and the β-common receptor (CD131). This receptor is distinct from the classical erythropoietic EPO receptor homodimer, which is the structural basis for the peptide’s separation of tissue-protective signaling from erythropoiesis — a widely studied model system in tissue-protection and anti-inflammatory research. Investigated strictly as a laboratory research compound, in in-vitro and preclinical models, ARA-290 is studied in the areas listed below. These are areas of scientific investigation only and are not claims of efficacy for any use.
Areas of Research
- •Innate repair receptor (IRR) pharmacology: Selective EPOR/CD131 heteromer activation without hematopoietic EPO-receptor stimulation.
- •Anti-inflammatory signaling: Modulation of macrophage activation and inflammatory/fibrotic responses.
- •Tissue-protection and nerve-repair models: Schwann cell and neuronal research models, nerve regeneration/remyelination, and microglial response.
Technical Data
- Amino Acid Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (pHBSP)
- Molecular Formula: C₅₁H₈₄N₁₆O₂₁
- Molecular Weight: ~1257.4 g/mol
- CAS Number: 1208243-50-8
- Synonyms: Cibinetide; pHBSP; Helix-B Surface Peptide
- Appearance: White lyophilized powder
- Purity: ≥99% (HPLC); identity confirmed by ESI-MS
- Contents: 10mg per 3ml vial
- Storage: Store lyophilized powder at -20°C; protect from light and moisture and keep tightly sealed; refrigerate reconstituted solution.