TB-500
$70.00
This research only product is supplied in a 3ml vial containing 10mg of TB-500 as a lyophilized powder. Every compound undergoes stringent independent 3rd party testing in a US laboratory with verified 99%+ purity and QR link to the COA stamped on the vial.
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For Research Purposes Only. This product is not intended for human consumption. By purchasing, you confirm that you are a qualified researcher and will use this product in compliance with all applicable laws and regulations.
Description
TB-500, a synthetic analog of thymosin beta-4 (TB4), primarily acts by binding to G-actin monomers to regulate actin polymerization, enhancing cell migration, tissue repair, and angiogenesis. This mechanism supports wound healing, reduces inflammation, and promotes vascular development across various tissues.
Mechanisms of Action
- •Actin Regulation: TB-500 binds globular actin (G-actin), preventing its polymerization into filamentous actin (F-actin), which increases actin monomer availability for dynamic cytoskeletal reorganization, cell motility, and migration to injury sites.
- •Angiogenesis Promotion: Upregulates vascular endothelial growth factor (VEGF), stimulates endothelial cell sprouting and tube formation, and stabilizes new capillaries to improve blood flow and nutrient delivery to damaged tissues.
- •Anti-Inflammatory Effects: Reduces pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6), suppresses NF-κB activation, and shifts macrophage polarization toward an anti-inflammatory M2 phenotype.
- •Growth Factor and Signaling Pathways: Activates Akt/PI3K for cell survival, enhances ERK1/2 and p38 MAPK signaling, upregulates hepatocyte growth factor (HGF), and promotes stem cell mobilization and differentiation.
Technical Data
- Form: Lyophilized powder
- Molecular Formula: C₃₈H₆₈N₁₀O₁₄
- Storage: Protect from light and moisture, keep tightly sealed, refrigerate reconstituted solution