SLU-PP-332 1mg

(60 CAPSULES)

This research only product is supplied in a in a small white tablet containing 1mg of SLU-PP-332.  Every compound undergoes stringent independent 3rd party testing in a US laboratory with verified 99%+ purity and QR link to the COA stamped on the vial.

Description

SLU-PP-332 is provided in 1mg per capsule oral capsules packaged 60 capsules per bottle.  It is considered a small molecule and not technically considered a peptide. The compound is manufactured and handled according to internal quality standards designed to support consistency, identity, and integrity for research workflows.

Additional information

SLU-PP-332 is a synthetic compound that functions as a potent estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It is classified as an exercise mimetic, meaning it replicates the metabolic benefits of physical activity without requiring actual exercise.

Mechanism of Action

SLU-PP-332 activates ERR proteins, which regulate cellular energy metabolism and mitochondrial function. The compound binds to a hydrophobic region adjacent to ERRα's ligand-binding domain, stabilizing the receptor's active conformation.This activation triggers a metabolic cascade that enhances energy expenditure, fatty acid oxidation, insulin sensitivity, and stimulates mitochondrial biogenesis.

Preclinical Effects

Research in animal models has demonstrated several promising effects:

·       Metabolic improvements: Counteracts metabolic syndrome in mice and normalizes metabolic profiles in cardiac tissue

·       Muscle enhancement: Increases type IIa muscle fibers, which have high capacity for breaking down sugars and fats, while inducing an exercise-like genetic program that improves endurance

·       Thermogenesis: Increases brown adipose tissue (BAT) activity by 50% in mice

·       Mitochondrial function: Increases mitochondrial DNA by 2.5-fold and enhances cellular respiration

·       Anti-aging markers: Reverses inflammatory and aging markers in preclinical studies