TB-500 10MG

This research only product is supplied in a 3ml vial containing 10mg of TB-500 (10mg) as a lyophilized powder.  Every compound undergoes stringent independent 3rd party testing in a US laboratory with verified 99%+ purity and QR link to the COA stamped on the vial.

Description

TB-500, a synthetic analog of thymosin beta-4 (TB4), primarily acts by binding to G-actin monomers to regulate actin polymerization, enhancing cell migration, tissue repair, and angiogenesis. This mechanism supports wound healing, reduces inflammation, and promotes vascular development across various tissues

Mechanism of Action

·       Actin Regulation: TB-500 binds globular actin (G-actin), preventing its polymerization into filamentous actin (F-actin), which increases actin monomer availability for dynamic cytoskeletal reorganization, cell motility, and migration to injury sites.

·       Angiogenesis Promotion: It upregulates vascular endothelial growth factor (VEGF), stimulates endothelial cell sprouting and tube formation, and stabilizes new capillaries to improve blood flow and nutrient delivery to damaged tissues.

·       Anti-Inflammatory Effects: TB-500 reduces pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6), suppresses NF-κB activation, and shifts macrophage polarization toward an anti-inflammatory M2 phenotype.

·       Growth Factor and Signaling Pathways: Activates Akt/PI3K for cell survival, enhances ERK1/2 and p38 MAPK signaling, upregulates hepatocyte growth factor (HGF), and promotes stem cell mobilization and differentiation.

These effects are primarily observed in preclinical animal models, contributing to applications in muscle, tendon, ligament repair, and systemic recovery, with high bioavailability via subcutaneous injection. Research emphasizes its role in actin dynamics as foundational for broader regenerative processes.